CONTENTSTHE INFLUENCE OF POLYMORPHISMS OF GENES OF INTERLEUKIN-I? AND RECEPTOR ANTAGONIST OF INTERLEUKIN-I ON THE DEVELOPMENT AND PROGRESSION OF CHRONIC HEART FAILURERevealed are the correlations between polymorphisms of gene IL-1? and the risk of development, severity and course of chronic heart failure, as well as with vasomotor disfunction of endothelium and systolic disfunction of left ventricle. INDICATORS OF ECHOCARDIOGRAPHY AND LEVEL OF NITROUS OXIDE IN MEN WITH ARTERIAL HYPERTENSION COMPLICATED BY CHRONIC CEREBROVASCULAR PATHOLOGYIndicators of echocardiography and level of nitrous oxide were studied in 234 men with arterial hypertension complicated by chronic cerebrovascular pathology. It was found that a high degree of endothelial dysfunction leads to a decline of myocardial function and brain perfusion which worsens the course of arterial hypertension and chronic cerebrovascular pathology. THE CLINICAL SIGNIFICANCE OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH BRONCHIAL ASTHMAQuantitative assessment of desquamated endothelium in the peripheral blood and parameters of computerized photo-pletismography of upper limb during tests with ischemia and inhalation of salbutamol in patients with varying severity of bronchial asthma revealed the development of endothelial dysfunction already at an early stage of the disease. Expression of vascular endothelial dysfunction was progressed in parallel to the severity of the disease and to the degree of remodeling both right and left parts of the heart in patients with bronchial asthma. FUNCTIONAL STATUS OF VESSEL ENDOTHELIUM AND PLATELETS IN POSTMENOPAUSAL WOMEN WITH ESSENTIAL ARTERIAL HYPERTENSION TREATED BY THE COMBINATION OF ACETYLSALICYLIC ACID AND CLOPIDOGRELConcentrations of von Willebrand factor, betathromboglobulin and 4th platelet factor were assessed in 170 women in postmenopause, which were divided into two groups depending on the degree of essential arterial hypertension, treated by the combination of acetylsalicylic acid and clopidogrel. The changes of markers of functional activity of platelets and markers of endothelial dysfunction indicate the possibility of pharmacological reduction of platelet activation in order to prevent thrombotic episodes in patients with arterial hypertension. FACTORS INFLUENCING THE ONE-YEAR FATALITY RATE AFTER THE ACUTE CORONARY SYNDROMEPresented are the data on possible ways of forming a genetic predisposition to the unfavorable course of coronary heart disease after the episode of aggravation. THE EFFECTIVENESS OF TRAINING PROGRAMS IN PATIENTS WITH RHEUMATOID ARTHRITIS AND SYSTEMIC OSTEOPOROSIS IN POLYCLINIC CONDITIONSThe effect of training in school of osteoporosis on the quality of life of postmenopause patients with rheumatoid arthritis and systemic osteoporosis was studied. The statistically significant improvement in the quality of life was found only 3 months later after learning. Taking into account the reduction of training effect 6 months after learning, it is recommended to carry out the educational. PREVALENCE AND REVELATION OF PRIMARY AND SYMPTOMATIC FORMS OF CHRONIC DAILY HEADACHE1225 patients with episodic and chronic headaches were under observation in specialized centers for diagnosis and treatment of pain in Samara and St. Petersburg. Cephalgia relevant to criteria of International Classification of Headaches for chronic daily headache was revealed in 49% of the cases. It was found that the primary diagnoses of chronic daily headache fully consistent with the criteria of International Classification of Headaches only in 6% of cases. The main reasons for discrepancy between primary and final diagnoses were identified. ALARMINGLY-DEPRESSIVE DISORDER AND QUALITY OF LIFE OF WOMEN IN POSTMENOPAUSEThe incidence of anxiety and depression among women depending on the type of menopause and their relationship to the clinical course of postmenopausal period and the quality of life were studied. Depression detected at 82.8% of women in postmenopause, and its expression depended on the type of menopause. Highlighted is the need for indepth survey of women in postmenopause period in order to reveal anxiety and depression with their subsequent timely correction. THE RELATIONSHIP OF DRUG ADDICT IDENTITY WITH THE AGE WHEN THEY START USING PSYCHOACTIVE SUBSTANCES110 respondents were surveyed to study the dependence of development of psychopatho-logical disorders from the time when they start using psychoactive substances. The respondents had different duration, course and prognosis of the addiction. The results of the analysis can help to organize primary and secondary prevention of addictmaking behavior and determine the work tactics with the sick. INDICATORS OF THE QUALITY OF LIFE IN PATIENTS WITH ERYSIPELASAnalyzed are indicators of quality of life among 141 patients with erysipelas. The improvement of these indicators was found after pathogenetic integrated treatment using aminophtal-hydrazide and laser. ENDOGENOUS INTOXICATION AND THE POSSIBILITY OF ITS CORRECTION DURING INFLUENZAIt was established that infectious process during influenza accompanied by significant expression of endogenous intoxication syndrome, which is multi-factorial in nature and accompanied by a decline of antioxidant system. An antioxidant, emoxipin, leads to correction of endotoxicosis and antioxidant protection that allows to recommend the drugs for use in other infections. ASSESSMENT OF ACETYLATION AND OXIDATION METABOLIC SYSTEMS IN PATIENTS WITH STREPTOCOCCAL TONSILLITIS AND THEIR THERAPEUTIC CORRECTION BY XYMEDONThe state of enzymatic acetylation and microsomal oxidation systems was studied in patients with streptococcal quinsy treated by ximedon correction. A relationship between clinical forms of the disease and biochemical processes in the organism was found. It is suggested that the inclusion of ximedon in pathogenetic therapy of quinsy is useful to correct the metabolic processes. OUTPATIENT SCLEROTIC SURGERY IN THE TREATMENT OF TROPHIC DISORDERS OF VENOUS ETIOLOGYThe treatment results of 60 patients with varicose disease of the lower limbs complicated by trophic ulcer are presented. The described methods have been used successfully in clinic for 9 years and have proven their effectiveness. A method of radio-frequency destruction of communicating veins allows safely and without additional cuts to stop the horizontal retrograde blood flow. USE OF UMBILICAL CORD BLOOD CELLS TO RESTORE INFECTED DEFECTS OF LONG TUBULAR BONES IN THE PRESENCE OF INFECTIONThe influence of umbilical cord blood cells on bone tissue regeneration was studied in 48 rats. It was found that umbilical cord blood cells have a catalytic effect on the regeneration of infected bone tissue and lead to full restoration of the anatomical and functional integrity of bone. In the control group (without umbilical cord blood cells) full regeneration of bone structure did not occure. ALTERNATIVE METHOD OF ANESTHESIA DURING HIP REPLACEMENTIt was found that during hip replacement in patients with cardiovascular pathology, more preferable is an alternative method of anaesthesia with warmed up to 38,5øC hypobaric bupivacaine. OUR EXPERIENCE TO DIAGNOSE AND TREATMENT OF PATIENTS WITH XANTHOGRANULOMATOUS PYELONEPHRITISAn assessment of clinical and laboratory data, radiation research methods, and results of surgical treatment of patients suffering from xanthogranulomatous pyelonephritis were discussed. Rational combination therapy using long intra-aortal infusion of drugs in the postoperative period avoided the complications of this fearsome disease, intrarenal urodynamic violations and saved the remainder function of kidneys. OXYGEN-DEPENDENT ANTIMICROBIAL SYSTEM OF NEUTROPHILS IN THE DYNAMICS OF OVARIAN CANCERMyeloperoxidase activity and indicators of spontaneous and induced NBT-test were studied in peripheral blood neutrophils of 145 patients with different stage of ovarian cancer. The tumor-progression-dependent reduction of myeloperoxidase activity in peripheral blood was found in patients compared with 120 donors, while no significant changes in NBT-test was determined at all stages of disease. CHANGES OF HUMORAL IMMUNITY OF PATIENTS WITH ADEQUATE THERAPY OF STAGE IIB BREAST CANCERHumoral immunological mechanisms of protection of patients with nodose breast cancer (IIB stage) were studied in the dynamics of adequate comprehensive therapy. The development of B-dependent immunodeficiency progressing during adequate chemo- and radiation therapy and surgical treatment was established. CHARACTERISTICS OF PLACENTAL CIRCULATION IN PREGNANT WOMEN WITH VARICOSE DISEASEDoppler-graphic assessment of blood flow in the arterial system of "mother-placenta-fetus" was studied in pregnant women with varicose disease. A correlation between the uterine-placental blood flow and assessment of newborn according to Apgar scale was established. It is suggested that this method can be used to diagnose the state of hypoxia and forecast the viability of the fetus and newborn. ORGANIZATION OF SPECIALIZED MEDICAL CARE TO PREGNANT WITH ACUTE PYELONEPHRITISThe treatment results of 583 patients with gestational pyelonephritis were presented. It was shown that improvements in diagnosis and treatment of patient with severe gestational pyelonephritis can be achieved only through systemic approach to meat the organizational, tactical, diagnostic and therapeutic targets. REASONS FOR THE DEVELOPMENT OF GENITAL PROLAPSE AFTER HYSTERECTOMY41 patients retrospectively analysed for genital prolapse after hysterectomy. Factors associated with a time of forming prolapse were the age when the first time fallout of internal genital organs happened, perineum injuries in childbirth, constipation, chronic cough, age at the time of hysterectomy, the presence of omission and the fallout before the hysterectomy, correction of fallout before the hysterectomy. Factors associated with the formation of a relapse genital prolapse were not normal physical work and a chronic cough. Factors associated with the age of beginning of genital prolapse were the menopause age and length of postmenopause period. THE ROLE OF DIAGNOSTIC ENDOMETRIAL BIOPSY IN GYNAECOLOGICAL PRACTICEA retrospective analysis of endometrial scraping of 3372 women was carried out. It was shown that the most frequent forms of pathology are endometrial polyps and gland hyperplasia. Endometrial cancer detected more often in women over the age of 50 years. Acyclic uterine bleeding, which was the reason for the abrasion of uterine cavity, was due to various endometrial pathology. Histological verification plays a crucial role in establishing the causes of age-related, hormonal and other violations in women body. GAS-FREE LAPAROSCOPY IN GYNAECOLOGY AS AN ALTERNATIVE METHOD TO CLASSICAL ENDOSCOPYPresented is an original method to perform laparoscopic gynaecological operations which were used on 120 patients. An evaluation of the effectiveness of the device was given to confirm the benefits of using isopneumatic regime in laparoscopic operations. FADEN-KUPPERS OPERATION IN RESTORING VISUAL FUNCTION IN PATIENTS WITH AMBLYOPIA AND MICRO-STRABISMUSDesigned was a tactic of adequate surgical treatment of patients with micro-strabismus. This tactic provides maximum visual symmetry axes, and thus allows to eliminate the conditions provoking relapse of amblyopia. FUNCTIONAL OUTCOMES OF RETINOPATHY IN PREMATURE BORN AND THEIR DEPENDENCE ON MACULA PATHOLOGYFunctional outcomes of premature retinopathy and their dependence on macula pathology were studied. Premature retinopathy was found in 30.1% of children with weight at birth less than 2500g. Low visual functions in children with various stages of scar retinopathy were due to incomplete foveola differentiation. THE FUNCTIONAL STATUS OF MYOCARDIUM IN NEWBORN AND INFANTSAn echo-and electrocardiographic survey of 32 newborns with pre-perinatal hypoxia was carried out. Analysis of data from children of first months of life revealed a lag of physiological adjustment of hemodynamics with compensatory increases of heart systolic values, and the results of electro-cardiography - electrical instability of myocardium of newborn which underwent pre-perinatal hypoxia. ENDOVASCULAR EMBOLIZATION OF LIVER MULTIPLE CAVERNOUS HEMANGIOMADiscussed are the results of superselective embolization hepatic artery in a patient with multiple cavernous of liver hemangioma. The method of endovascular embolization of multiple cavernous of liver hemangioma could serve as an effective alternative to open surgical methods of treatment and more widely used in this category patients. DISTAL RESECTION OF THE PANCREAS IN TREATING PATIENTS WITH RECURRENT CYSTS OF CORPOCAUDAL LOCALIZATIONThe results of the distal resection of the pancreas in patients with recurrent cysts of corpocaudal localization are presented. Technical improvements of the operation reduced the frequency of postoperative pancreatitis and development of pancreonecrosis. THE IMPACT OF ADVERSE FACTORS DURING PRODUCTION OF ETHYLBENZENE AND STYRENE ON PARADENTIUMThe comparative analysis of the tissue paradentium from people working in conditions of the impact of unfavorable factors petrochemical production was performed. The dependence of the incidence and intensity of inflammatory lesions of paradentium on time and degree of exposure to xenobiotics was established. A COMPREHENSIVE ASSESSMENT OF HYGIENE, ENVIRONMENTAL AND TECHNICAL EFFICIENCY OF INDUSTRIAL EMISSIONS TREATMENT SYSTEMSAnalyzed were strengths and weaknesses of the gascleaning systems in Russia and abroad. A parameter, characterizing complex hygiene, environmental and technical excellence gas-cleaning system was introduced. A numerical study of the dispersion of emissions in the atmosphere through the methods of computational hydrodynamics was carried out. THE HEALTH STATE OF LABORATORY TECHNICIANS WORKING IN MODERN PETROCHEMICAL INDUSTRYHygienic laboratory evaluation of labour conditions in the petrochemical industry showed that in the process of work they are in contact with substances of 2-4 Grade danger. It was found that leading pathologies in women were disease of autonomic nervous system, gastrointestinal tract, ENT-organs and cardiovascular system. A laboratory technicians who have close contact with toxic substances, revealed a disorder of reproductive health. It was suggested that to reduce the risk factors it is necessary to create professional monitoring of working conditions and the health of women working in the petrochemical industry. THE ROLE OF SMOKING AND INDUSTRIAL AEROSOLS IN THE DEVELOPMENT OF COPD AMONG WORKERS OF METALLURGICAL INDUSTRY150 workers of main workshops of metallurgical production with clinical manifestations of chronic obstructive pulmonary disease or having serious risk of its development were under observation. Disorder of antioxidant protection and increase of processes of lipid peroxidation were identified in all the surveyed persons. The leading role of industrial aerosols in the development of the disease in case of excess dust load 10 times more than normal was established. Reaffirmed was the leading role of smoking, which contributed 5 times higher than the contribution of dust. THE SELECTION OF ESSENTIAL MEDICINES IN THE REGIONAL DRUG POLICYThe strategy of choice, criteria and procedure of forming a list of essential medicines were discussed under national drug policy. THE EVOLUTION OF THE SYSTEM OF COMPULSORY HEALTH INSURANCE BY THE EXAMPLE OF THE WORK OF CHILD-OUTPATIENT POLYCLINIC INSTITUTIONThe evolution of current fiscal and insurance financing model, which is an integral part of compulsory health insurance and its transition to the insurance, most close to modern economic realities, is discussed. REALIZATION OF PRIORITY NATIONAL PROJECT "HEALTH" IN THE KEMEROVO REGIONWithin the priority national project "Health", a longitudinal study to monitor mental and physical health of students in the learning process in higher education in environmentally disadvantaged region was carried out. The results of monitoring the health of students should be used in health services and education by municipal authorities in order to preserve the health of young people, reduce morbidity, the formation of values of health and improve the quality of teaching of high school students. AN ANALYSIS OF THE INCIDENCE OF CHRONIC RENAL FAILURE IN THE REPUBLIC OF TATARSTANEpidemiology of chronic renal failure due to primary and secondary chronic kidney diseases in adult population was studied in the Republic of Tatarstan for the period of 1999-2005. Tendency to higher morbidity of chronic renal failure than incidents of chronic kidney diseases was established. DEVELOPMENT OF A NEW METHOD OF PRESERVING VIABLE LEUKOCYTES IN NEAR-ZERO TEMPERATURE CONDITIONSAn effective and economical method of preservation of viable leukocytes in near-zero temperature conditions for 6 days by using an original protective solution is described. DETERMINING THE VIABILITY OF A SEGMENT OF SMALL INTESTINEA method to test viability of small intestine segment was developed in 130 experiments on 15 rabbits and was used in 4 patients. A METHOD OF GENTLE URANOSTAPHYLOPLASTY PREVENTING THE SHORTENING AND SCARRING OF SOFT PALATEA new gentle method of uranostaphyloplasty was used in 108 patients aged 2 to 7 years. Visually good results from operations were achieved in 96 (89%) patients and satisfactory - in 12 (11%). THE SUCCESSES AND FAILURES IN THE TREATMENT OF HYPERKINETIC WRINKLES IN MEN: ALGORITHM FOR DERMATOVENEREOLOGISTAn algorithm to treat patients with hyperkinetic wrinkles using botulinum toxin type A was described. It was found that treatment by the introduction of botulinum toxin type A was highly effective if used by long-term medical practitioners who use psychological methods of correction, adequate doses of medication according to muscle mass and extent of its hyperactivity. © 1995-2008 Kazan State University |