CONTENTS
RELATIONSHIP BETWEEN HUMORAL AND ANTIBACTERIAL IMMUNITY AND OXYGEN DEPENDENT METABOLISM OF NEUTROPHILS IN CHILDREN OF EARLY AGE WITH DIFFERENT VARIANTS OF BRONCHITISIn the relapsing nature of obstructive bronchitis as in the case of acute obstructive bronchitis the percent of children with polyimmunization in the given variant of bronchitis reached 63,2% of the number of examined persons. In bronchial asthma the phenomenon of polyimmunization was typical for all examined persons of the given group, in this case in the majority of children the level of antibodies was high to 5-6 antigenes and in some of them even to 7-8 antigenes. The level of spontaneous luminol dependent chemoluminescence at the height of the disease was higher than 1000 imp/min in the children with the phenomenon of polyimmunization. The results show the relationship between oxygen dependent metabolism of polymorphonuclear leukocytes and natural polyimmunization depending on the genesis of the pathological process of the bronchial tree. CURRENT TRENDS IN THE TREATMENT OF THE OPEN ARTERIAL DUCTThe experience of work of the cardiosurgical department of the Children medical centre on the diagnosis, treatment and postoperative dispensary examination of patients with open arterial duct is generalized. The Botallo,s duct was closed by surgical method in 92 patients making up 18,4% of the total number of operated patients, catheterization of heart cavities was performed in 88 children. For closing the open arterial duct the various operation techniques were carried out: the dressing of the duct from aorta out of the anterolateral access (1%), out of the posteriorlateral access from aorta (85,8%), as to recanalization out of the anterolateral access from aorta and pulmonary artery intrapericardially (1%), clipping of the duct out of the minithoracotomic access (8,7%), videothoracoscopic clipping (3%). The operated children are under examination of the cardiologist throughout the year with visits every month, three months, 6 months and one year. USE OF XYMEDONE IN SURGICAL PRACTICE FOR INCREASING NONSPECIFIC RESISTANCE OF THE ORGANISM TO INFECTIONSTwo groups of patients with various forms of acute appendicitis taking a drug of pyrimidine series, xymedone (102 patients) and methyluracil (138 patients) are examined. Nonspecific resistance of the organism to infection is estimated by the results of determining the functional activity of blood neutrophils, concentration of bioactive and immunoreactive fibronectin in blood plasma, activity of the fibrinostabilizing blood factor (factor XIII). Xymedone increases nonspecific resistance of the organism to infection by strengthening the functional activity of neutrophils, their reserve potentials. The use of xymedone in clinical surgery for increasing nonspecific resistance of the organism to infection is advisable. EXPERIMENTAL AND CLINICAL VALIDITY OF THE USE OF XYMEDONE AS AN ANTIOXIDANT IN THE COMPLEX TREATMENT OF PATIENTS WITH CHRONIC OSTEOMYELITISThe antioxidant activity of blood plasma is studied in patients with chronic osteomyelitis. The experimental data on the effect of antioxidants of xymedone and methyluracil on the basic free radicals, peroxide oxidation of lipoids and chemoluminescence of peritoneal macrophages of rats made it possible to justify the use of drugs in the complex treatment of patients in pre- and postoperative period. As a result of the use of xymedone in the complex treatment the blood indices improved, antioxidant plasma activity increased in 25 patients of the basic group. In patients of the control group taking methyluracil the efficiency of the treatment was less significant. |
RETINOIC ACID DRUGS IN THE COMPLEX TREÀTMENT OF ACUTE PROMYELOCYTE LEUKOSISThe results of the treatment of 11 patients with acute promyelocyte leukosis using the retinoic acid drugs (ATRA, 13-cis-retinoic acid) are presented. Total remission was achieved in 6 out of 9 patients within 22-39 days of treatment: in 2 patients - on ATRA monotherapy and in 4 patients - in combination with polychemotherapy. Normalization of hemostasis indices with tendency to hypercoagulation is noted during the first week. Cupping of hemorrhages took place within 14-30 days of treatment. High incidence (67%) of the retinoic acid syndrome is noted. It is connected with the initial hyperleukocytosis and not always timely prescription of polychemotherapy. Less dramatic nature of the disease course, fast cupping of hemorrhages, absence of the bone marrow aplasia phase, decrease of demand in transfusional provision were observed in using ATRA. DETECTION OF HELIÑÎBACTÅR PYLORI IN THE DISEASES OF GASTROENTERIC TRACT AND ORAL CAVITY ORGANS IN CHILDRENThe role of Helicobacter pylori in the development of the diseases of digestive organs is considered. The possibility of colonizing these microorganisms of the mucous membrane of oral cavity organs in children with gastroduodenal pathology is studied. The immunohistochemical method made it possible to detect Helicobacter pylori not only in dental deposit and saliva but also on the mucous membrane of oral cavity organs, on the tongue surface and gingivital margin. PREREQUISITES TO THE USE OF DIMEPHOSPHONE FOR THE TREATMENT OF EROSIVE AND ULCEROUS DISEASES OF GASTRODUODENAL ZONEThe therapentic activity of dimephosphone in erosive and ulcerous processes in gastroduodenal zone is revealed by the experiments on 34 rats and observations of 148 patients. The increase of the medicinal effect of therapy with dimephosphone is determined, in particular, by suppression of the HCl production by means of parietal cells of the stomach owing to inhibition of the calcium dependent discharge of endogenic histamine out of enterochromaffin like cells. ON THE PATHOGENESIS OF THE DIVERTICULUM DISEASEThe results of examination of 130 patients with the irritable colon syndrome are analyzed. The patients were divided into 4 groups depending on the disease duration (up to 3 years - 40 patienrs, from 3 to 6 years - 40 patients, from 6 to 10 years - 30 patients, more than 10 years - 20 patients). Morphological and clinical manifestations characteristic of the diverticulum disease were determined by the process duration. LOCALIZED AND PRIMARILY MULTIPLE BIOLITHIASISThe rate of detecting biliary, urinary and salivary biolithes on the sectional material is not rare and is 10,6% of the general number of autopsies: cholilithiasis - 8,7%, urolithiasis - 6,4%, sialolithiasis - 1,03%. The primarily multiple biolithiasis in the given systems is revealed in 3,4% of the cases. Throughout the life of patients biolithes were found only in 12 patients in particular, when the death resulted from the complications of the urolithic or cholelithic diseases. Sialolithiasis, especially the primarily multiple biolithiasis was not diagnosed in none of the cases throughout the life of patients. EFFECT OF FACTORS OF THE ANTENATAL PERIOD OF PREGNANCY ON THE FORMATION OF PSORIASIS IN CHILDRENThe accompanying diseases during pregnancy (gastroenteric tract diseases, neuroses), complications during pregnancy (toxicoses), stress situations have the essential effect on the formation of psoriasis in children. It should be taken into account in performing medicosocial prevention of this dermatosis in children. |
TREATMENT OF INJURIES OF HAND FINGER EXTENSORSThe nature of operative and treatment methods depending on the terms of trauma and injury levels in 134 patients with injuries of hand finger extensors is established. The tråatment method stereotype of injuries of hand finger extensors is developed. The internal splinting is typical and the most adequate treatment method for the 1st injury zone; the buried tendon sutures with temporal (to three weeks) fixation of the joint by the wire to accretion of the sutured ends of the injuried tendons are typical for the 2d zone; the primary and secondary tendon sutures with the palmar plaster bandage to accretion of tendons are typical for the 3d zone, the most favourable zone for recovery; the primary or secondary tendon sutures with the absence of defect butween tendon ends are typical for the 4th zone, and with defect more than 3-5 sm the free bridge-like plasty by autotransplant is typical. In chronic injuries of one - two finger extensors when defect is more than 5 sm the transposition is advisable, that is switching the distal extensor end over to the new motor muscle. POSTERIOR URETHROSCOPY IN THE TREATMENT OF MEN WITH CHRONIC PROSTATITISThe use of posterior urethroscopy has obvious diagnostic and therapeutic value because it makes it possible to increase the efficiency of the treatment course and significantly to decrease the number of season acute conditions of chronic prostatitis. USE OF GRANDAXIN IN PATIENTS WITH POSTCASTRATION SYNDROMEThe results obtained in the treatment of 14 women (45,6±1,6 years) with postcastration syndrome confirmed the vegetostabilizing properties of grandaxin. It is advisable to include grandaxin (0,1½ twice daily) into the complex therapy of postcastration syndrome. LEVEL OF THE USE OF BIOMETRICAL METHODS IN RUSSIAN PERIODICALSThe level of the use of two biometrical methods most frequently applied in Russian biological and medical periodicals is analyzed. The data are based on material processing of more than 100 issues of magazines of 19 names. The sequence of magazine names according to their biometrical rating is proposed. ON THE ATTESTATION OF WORKING PLACES IN AGRICULTURAL PRODUCTIONAgricultural production belongs to one of the least favourable braches as to sanitary and hygienic, demographic, social and economic indices. In this connection the attestation of working places by labour conditions of the given brach is timely and important stage on the way to providing safe labour conditions meeting the requirements of hygiene and decreasing professional risk. The operative correction of the leading documents is necessary for increasing the effeciency of the attestation of working places. © 1995-2008 Kazan State University |