CONTENTS
PREVALENCE AND PREVENTION SYSTEM OF CONGENITAL DEVELOPMENTAL DEFECTS IN TATARSTAN REPUBLICThe prevalence of congenital developmental defects among children in Tatarstan Republic and its dynamics for the last five years are studied. Their role in mortinatality structure, infant mortality is analyzed. The program of preventing congenital defects by creating the prenatal diagnosis service including the US screening of pregnants, medicogenetic consultation, invasive methods of prenatal diagnosis is suggested. The introduction of the current monitoring of congenital developmentale defects is necessary to control the efficiency of the suggested prevention measures. A PLACE OF PALLIATIVE OPERATIONS IN THE TREATMENT OF PATIENTS WITH THE FALLOT'S TETRADAs many as 42 children with the Fallot's tetrad aged 3 months to 9 years, 32 (78%) children up to 3 yeaes were examined and operated in the cardiac surgery department of the Children Medical Center of Kazan from 1995 to 1998. The palliative operations were performed in 30 patients. The radical correction of the Fallot's tetrad was performed in 17 patients, it was repeated in 5 children in terms from 1 to 3 years after the previonsly performed palliative operations. Mortality was not high. In various age groups the differentiated approach taking into account the initial state gravity makes it possible to obtain good results in the treatment of one of the most dàngerous congenital heart diseases. Urgent palliative operations make it possible to save life of patients of early age and to prepare them for radical operations. HEALTH OF PRESCHOOL AGED PREMATURELY BORN CHILDRENThe combined clinical social examination of 118 children prematurely born of the I-II degree is carried out. As many as 118 children born at full terms, selected as case-control (by sex, age) are examined for comparison. The preschool aged children prematurely born children had higher morbidity level according to taking medical advice, examination data including psychic behaviour disorders and insufficient physical development. The obtained results should be taken into account in clinical examination of such children. EFFECT OF THE COMBINATION OF DIMEPHOSPHONE AND XIMEDONE ON THE LOCAL IMMUNITY STATE OF ORAL CAVITYThe effect of the combination of ultraphoresis of 15% dimephosphone aqueous solution and administration of xymedone on the local immunity state of oral càvity in combined prevention of dental caries is estimated. The used treatment promotes reliable improvement of the local immunity indicators of oral cavity. VARIATION OF ENZYME LEVELS IN BLOOD IN NONSPECIFIC PULMONARY DISEASESLevel of different ensymes was determined in blood serum of patients with bronchial asthma, chronic obstructive bronchitis, chronic nonobstructive bronchitis, pneumonia and 22 healthy persons. In severe chronic obstructive bronchitis in contrast to bronchial asthma, the increase of activity in blood serum was found which can serve as a differential and diagnostic indicator. In the acute phase of pneumonia and severe chronic nonobstructive bronchitis the increase of alkaline phosphatase, gamma-glutanul transferase activities occurred, and in pneumonia activity of aminotransferases increased as well. By discharde of patients from the hospital the studied indicators remained elevated. It is necessary to continul the search of further ways of Correction of enzyme changes with estimation of prognostic value of some indicators in case of favoreble outcome of pulmonary diseases. CÎMPARATIVE ESTIMATION OF WORK CAPACITY OF PATIENTS WITH PEPTIC ULCER AFTER STANDARD STOMACH RESECTION AND DUODENOPYLOROPLASTYThe comparative estimation of labour capacity after two various operation methods: standard stomach resection and duodenopiloroplasty is given. It is established that the organopreserving operation method provides higher health level of the patient with peptic ulcer. The suggested method is efficient in medical as well as in social and economic aspect. BILIOBILIARY FISTULASThe results of the treatment of 27 patients with biliobiliary fistulas - serious complications of cholelithiasis which for the most part were not diagnosed before operations and were unexpected during interventions as to cholecystitis or mechanical jaundice are given. The operative treatment presents difficulties and should be directed both to the elimination of biliobiliary fistulas and to the correction of patholigic changes in biliary ducts. Five cases of successful treatment of biliobiliary fistulas by miniaccess are given. The postoperative mort ality was 22,2%. POSSIBILITIES AND PROSPECTS OF LOWINVASIVE SURGERY OF VARICOSITYThe described ambulatory treatment method of varicosis of the II-III degree makes it possible to extend the indications to the conservative treatment, on veins and to obtain the steady good effect comparative with the operative phlebectomia effect but without its traumatism, to achieve high cosmetic results and fast recovery of capacity for work. REVEALING OF HEMOCOAGULATIVE ACTIVITY OF LEUKEMIA CELLS IN ACUTE MYELOBLASTIC LEUKEMIA AND CHRONIC MYELOLEUKEMIAPeripheral blood and punctates taken in 13 primary patients, 6 of which had acute myeloblastic leukemia and 7 - chronic myeloleukemia are studied. The peripheric blood in 3 healthy volunteers is studied for control. The method of revealing the tissue factor activity in blood cells of patients with leukemia is suggested. Previously described expression of the tissue factor by myeloblasts of patients with acute myeloblastic leukemia in peripheral blood as well as in bone marrow punctates is confirmed. It is shown that in patients with chronic myeloleukemia expression of the tissue factor activity is carried out by myeloblasts in peripheral blood as well as in bone marrow punctates. The results contradict the conception maintaining the principal impossibility of forming prineipal the tissue factor by blood cells. The development of disseminated intravascular blood coagulation syndrome and hemophilia under the influence of the tissue factor in leukocytes is possible not only in acute myeloblastic leukemia but in chronic myeloleukemia. EFFECT OF SYNTHETIC ANTIDIABETIC AGENTS ON THE SERUM ALBUMIN GLYCATION PROCESSSynthetic antidiabetic agents (glyphormin, glyclaside, glycvidone, glybenclamide) in incubation of high concentrations of glucose with human serum albumin in experiments in vitro can diminish glycation process. In mild glycation regime the effect of agents becomes more prolonged and pronounced. The protein glycation leved in constant glucose concentration in rats with alloxan induced diabetes decreases while injecting them with glyphormin, glycvidone and and glybenclamide during a month. EFFECT OF CHLODITANE ON THE CONTENT OF GLYCOSAMINOGLYKANES IN BLOOD AND LIVER OF RATS WITH ALLOXAN DIABETESHypoglucocorticoidemia caused by systemic injection of chloditane {[2(chlorphenil)-2-(4-chlorphenil)-1]-1 dichlorethane} promotes normalizing the content of glycosaminoglykanes in blood of rats with alloxan diabetes. Òhe increase of concentration of the total glycosaminoglykanes in liver tissue of these rats on the 30th day occurs as a result of their accumulation. The determination of the content of sulphatized glycosaminoglykanes can be used to reveal the metaboliñ disorders in the connective matrix in alloxan diabetes. © 1995-2008 Kazan State University |